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Depressive disorder refers to a category of mood disorders characterized by significant and persistent low mood caused by various factors. Clinically, it primarily manifests as a low mood that is disproportionate to the individual's circumstances, ranging from feeling down to extreme sorrow, and in some cases, even stupor. Some patients may exhibit noticeable anxiety and psychomotor agitation, while severe cases may involve psychotic symptoms such as hallucinations and delusions. Some patients may engage in self-harm or suicidal behavior, which can lead to death. The typical course of depressive disorder is episodic, but 20%-30% of cases follow a chronic course, leading to more medical issues and a poorer long-term prognosis. Dysthymia is the most common type of chronic depressive disorder, particularly prevalent in primary care settings and among patients with chronic illnesses. Major Depressive Disorder (MDD) is the most common type of depressive disorder, characterized by single or recurrent episodes with a high risk of relapse. During episodes, significant emotional, cognitive, and physical symptoms are present, while symptoms subside during remission periods. Nanjing Healed Gene Biotechnology Co., Ltd. uses fluorescence PCR technology to detect the levels of four circular RNA (circRNA) biomarkers in human plasma samples in vitro. The detection results, combined with clinical standard diagnostic methods, can be used for the clinical auxiliary diagnosis of MDD. Circular RNA Detection Kit : Pioneering a New Era of Precision Diagnosis and Treatment for Mental Disorders, Safeguarding a Happy and Fulfilling Life!  

Circular RNA (circRNA) is a unique class of non-coding RNA molecules characterized by their closed-loop structure, widely present in eukaryotic transcriptomes. Most circRNAs are composed of exon sequences and exhibit conservation across different species, as well as tissue-specific and developmental stage-specific Major Depressive Disorder (MDD). Due to their resistance to nucleases, circRNAs are more structurally stable than linear RNAs. With advancements in bioinformatics and high-throughput sequencing technologies, a large number of circRNAs have been discovered and identified, leading to an increased understanding of their functions. On one hand, circRNAs can bind to corresponding microRNAs, acting like "sponges" to adsorb miRNAs, preventing them from binding to target genes and thereby co-regulating the expression of target genes. On the other hand, circRNAs can directly regulate other RNA levels through base pairing or interact with RNA-binding proteins (RBPs) to influence gene expression. In summary, circRNAs may serve as objective clinical diagnostic markers and valuable targets for disease treatment. Nanjing Healed Gene Biotechnology Co., Ltd. utilizes fluorescence PCR technology to detect the levels of four circular RNA (circRNA) biomarkers in human plasma samples in vitro. The detection results, combined with clinical standard diagnostic methods, can be used for the clinical auxiliary diagnosis of MDD. Circular RNA Detection Kit : Pioneering a New Era of Precision Diagnosis and Treatment for Mental Disorders, Safeguarding a Happy and Fulfilling Life!